Communiqué de presse conjoint avec l’Université de technologie Chalmers – 10 septembre 2015]
New research enables "tailored" diet advice – based on our personal gut microbiome – for persons who want to lose weight and reduce the risk of disease. Systems biologists at Chalmers University of Technology have for the first time successfully identified in detail how some of our most common intestinal bacteria interact during metabolism.
Obesity is caused by many complex factors, some of which are yet unknown. Researchers from the French National Centre for Scientific Research (CNRS), Inserm, Pierre and Marie Curie University (UPMC) and Paris Descartes University, in collaboration with clinician researchers from the Paris Public Hospitals (AP-HP), have just shown that severe obesity is accompanied by inflammation of the small intestine and a strengthening of the immune defences in that area. This phenomenon reduces enterocyte sensitivity to insulin and increases nutrient absorption, thus exacerbating the disease. This work, carried out at the Cordelier Research Centre (Inserm/UPMC/Paris Descartes University) and the Institute of Cardiometabolism and Nutrition (ICAN – Inserm/UPMC/AP-HP), is published on 18 June in the journal Cell Metabolism.
Read the full press release here
Press release – Inserm press room – The small intestine is involved in chronic inflammation in obese people
Also available in French
Paris, 22 November 2012
METACARDIS (Metagenomics in Cardiometabolic Diseases) is a European project coordinated by Inserm that aims to study the role of the gut microbiota in the development of cardiometabolic diseases (CMDs). Thanks to the support of the European Commission, fourteen partners in six European countries will work together over a five-year period to translate the results obtained with novel CMD diagnosis and treatment methods and pave the way for personalised medicine in CMDs. Researchers and clinicians from the Institute of Cardiometabolism and Nutrition (ICAN) will also be involved in the METACARDIS project.